Rheumatoid Arthritis from Pathogenesis to Therapeutic Strategies

Therapeutic strategies for rheumatoid arthritis.

It affects approximately 0.8 percent of adults worldwide, 2 is more common in women (by a ratio of 3 to 1), and has an earlier onset in women, frequently beginning in the childbearing years. 3 Recent advances in understanding the cytokine networks that are responsible for the ongoing inflammatory response in rheumatoid arthritis 4 have led to the successful use of therapies that target tumor ne...

Therapeutic Strategies in Amyloid A Amyloidosis Secondary to Rheumatoid Arthritis

Amyloidosis is a disorder of protein conformation and metabolism that results in the depo‐ sition of insoluble amyloid fibrils in tissues, which causes organ dysfunction; systemic amy‐ loidosis is characterized by failure of multiple organs and the presence of amyloid precursor protein in the serum [1-3]. Reactive amyloid A (AA) amyloidosis is one of the most severe complications of several chr...

Pathogenesis of Rheumatoid Arthritis

[Pathogenesis of rheumatoid arthritis].

Rheumatoid arthritis (RA) is an autoimmune systemic disease that primarily affects joints. Etiology and the pathogenesis of RA are complex, involving many types of cells, among others macrophages, T and B cells, fibro- blasts, chondrocytes and dendritic cells. Despite well documented role of many genes and epigenetic modifications in the development and evolution of the disease, in most RA pati...

Bone loss in osteoporosis and arthritis. Pathogenesis and therapeutic strategies.

Bone makes up a framework that provides protection for internal body organs. The homeostasis of bone is maintained by balanced old bone resorption and new bone formation. However, this balance can be altered such as in postmenopausal women, patients with some cancers, and patients with chronic inflammatory conditions such as rheumatoid arthritis. In recent years, the management of chronic infla...